Colchicine is a mean for treatment of sharp attacks of a gout (sharp gouty arthritises), influencing an exchange of uric acid. Colchicine expressed anaesthetising and anti-inflammatory an effect has at a sharp attack of gout.
The great value in the action mechanism of Colchicine has reduction of formation of lactic acid that warns shift рН in a interstitial fluid and limits to that crystallisation of uric acid. It is applied strictly under the doctor's instruction.
Colchicine is applied regularly on an empty stomach inside. It is not supposed to apply 2 doses simultaneously. At a long break in reception of Colchicine, it is better to repeat course of treatment anew.
After intake it is well soaked up from a gastroenteric path. The maximum concentration in plasma is reached within 2 hours. It is deduced in a kind metabolites by kidneys and through intestines.
Store Colchicine in a dry and dark place, far from children and animals. Storage of Colchicine in a bathroom is counter-indicative. Optimum temperature of storage is 77 degrees F (25 degrees C). Short storage is to be at temperature of 59-86 degrees F (15-30 degrees C).
Colchicine Safety infomation
Contra-indications:
- A hypersensibility to Colchicine;
- At treatment by Colchicine it is counter-indicative there are grapefruits and to drink grapefruit juice;
- Alcohol is counter-indicative;
- Simultaneous reception with other medicines causing drowsiness;
- Pregnancy, heavy nephritic and-or hepatic insufficiency.
It is counter-indicative to application at pregnancy and during a lactation because Colchicine it is found out in breast milk.
Collateral action: From a gastroenteric path: a nausea, vomiting, a diarrhoea, a pain in a stomach.
Special instructions: With care apply at patients of advanced age, at diseases of kidneys, a gastroenteric path, heart. At treatment by Colchicine the control of peripheral blood is necessary.
Colchicine Side effects
From the party urogenital system: infringement of function of kidneys.
From blood vascular system: leucopenia (reduction of leukocytes in blood); at long application - agranulocytosis.
Dermatological and allergic reactions: (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; infection; numbness or tingling; severe diarrhea; sore throat; tiredness; unusual bleeding or bruising; weakness.
At sharply expressed by-effects consultation of the doctor is necessary.
