Prednisone is a synthetic (man-made), oral corticosteroid. It is used for suppressing the immune system and inflammation. Here are mentioned the most common and established uses of Prednisone, though it is used in many conditions. Most often Prednisone is used for treatment of ulcerative colitis, several types of arthritis, systemic lupus, Crohn's disease, asthma, severe psoriasis and allergic reations.
Some of effects of Deltasone are similar to other corticosteroids, like dexamethasone (Decadron), prednisolone (Prelone), methylprednisolone (Medrol), and triamcinolone (Kenacort). These synthetic corticosteroids imitate the cortisol’s (hydrocortisone) action. Cortisol is naturally-occuring corticosteroid that is produced by adrenal glands in the body. Although corticosteroids may affect the body in different ways, they are commonly used for their strong anti-inflammatory effects, especially in conditions where the immune system plays an important role, such as: colitis, arthritis, asthma, bronchitis, certain skin rashes, and inflammatory or allergic conditions of eyes and nose. Prednisone is not active in the body until it’s converted to prednisolone by enzymes in the liver. Only after that it becomes effective. Consequently, Prednisone may not be effective enough in people with liver disease, because their ability to convert Prednisone to prednisolone is weakened.
Also it is used for treating lymphomas, leukemias, autoimmune hemolytic anemia, and idiopathic thrombocytopenic purpura. Corticosteroids (including Prednisone) are usually used for suppressing the immune system, and preventing the body from rejecting the organs that were transplanted. Prednisone is also used as replacement therapy in case if patient's adrenal glands aren't able to produce sufficient amounts of cortisol.
The starting dose of Prednisone may vary, depending on the age of the patient, and the condition being treated. The dose for start may vary from 5 to 60 mg per day. Dose is often adjusted, based on the response of the condition being treated. Corticosteroids should be used for several days to see their maximal effects, because they typically don't produce maximal effects. Sometimes it may take much longer to see the conditions respond to treatment. Adrenal glands atrophy and stop producing cortisol in case when therapy with Prednisone is prolonged. The dose of Prednisone is to be lowered gradually to let the adrenal glands some time to recover, if a prolonged therapy of Prednisone is interrupted, serious side effects may occur. Prednisone is recommended to be taken with food.
If you are taking the dose daily, and if you missed one, take it as soon as you remember. Nevertheless, skip the missed dose if you don’t remember until the next day. Then continue taking only your regular daily dose. In case if you are to take more than one dose daily, you can take the dose that you missed as soon as you remember, or take two doses at the next dose time. If you are prescribed to take the dose every other day, try to take the missed dose as soon as you remember. After that continue with your regular every-other-day schedule.
Store Deltasone at room temperature between 68 – 77 degrees F (20 – 25 degrees C), away from moisture.
Deltasone Safety information
Do not drink alcoholic beverages. Together with Prednisone, alcohol may damage the stomach. Try to avoid sources of infection. Keep your hands clean washing them frequently, and keep them away from your face (mouth and eyes). While taking Prednisone your immune system may be weakened. And don’t take any immunizations during therapy with Prednisone, not having discussed it with your doctor. Prednisone may interact with phenytoin (Dilantin), and estrogens, which can reduce enzymes’ action in the liver that eliminate or break the active form of Prednisone – prednisolone. The level of prednisolone may increase and, as a result, lead to more frequent side effects. Phenytoin increases enzymes’ activity in liver, which break down/eliminate Prednisone, and thus, may reduce the effectiveness of Prednisone. Thereby, an increased dose of Prednisone may be required in case if phenytoin is being taken. Corticosteroids cross the placenta into the fetus, but compared to other corticosteroids Prednisone, however is less likely to cross the placenta. If corticosteroids are used chronically during the first trimester of pregnancy, then there appears a risk of cleft palate. Corticosteroids also are secreted in breast milk, and may cause some side effects in the infant, although Prednisone is less likely than other corticosteroids to be passed into breast milk. But it may still present a risk for the infant.
Deltasone Side effects
Side effects of Prednisone, and other corticosteroids may range from mild bothering to serious irreversible damage. The higher the dose is and the longer treatment is – the bigger is the chance for side effects to occur. Side effects include such as gaining the weight, retention of fluid and salt (sodium), high blood pressure, headache, loss of potassium, and weakness of muscles. Prednisone may also cause moon face (puffiness of the face), thinning and easy bruising of the face, growth of facial hair, glaucoma, cataracts, impaired healing of wounds, worsening of diabetes, ulcers in duodenum and stomach, irregular menses, obesity, rounding of the upper back (“buffalo hump”), convulsions, retardation of children’s growth, and psychiatric disturbances. Psychiatric disturbances may include: depression, insomnia, euphoria, mood swings, personality changes, or even psychotic behaviour. Prednisone suppresses the immune system, and consequently increases the frequency/severity of infections. At the same time it diminishes the vaccines’ and antibiotics’ effectiveness. Prednisone may cause bones fracture, as a result of osteoporosis. That’s why those patients that are taking Prednisone for a long period of time, are often prescribed to receive supplements of calcium and vitamin D. However calcium and vitamin D are not probably enough, therefore treatment with bisphosphonates, such as aledndronate (Fosamax), and risedronate (Actonel) may be needed; Miacalcin (Calcitonin) is effective too. The utilisation of density scans may help monitoring the development of osteoporosis, and the need for its treatment.
Stop taking Prednisone in case if you experience any of the listed below serious side effects, and contact your doctor, or seek for medical attention immediately: an allergic reaction (closing of your throat; difficulty breathing; hives; swelling of your face, tongue, or lips); sudden weight gain (more than 5 pounds in a day or two); or increased blood pressure (blurred vision, or severe headache). Other side effects that are less serious may be more likely to happen. Keep taking the Prednisone and consult with your doctor if you experience such side effects as: insomnia; vomiting, nausea, or stomach upset; muscle weakness or joint pain; dizziness or fatigue; increased thirst or hunger; or problems with diabetes control. Other side effects may occur very rarely in cases of taking the high doses of Prednisone include increased hair growth, acne, cataracts, thinning of the skin, glaucoma, osteoparosis, roundness of the face, and changes in behaviour. Some side effects, that aren’t listed above may also happen. If any side effect is especially bothersome, or seems unusual to you, talk to your doctor about them.